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mail stuck in exchange mail queue

hi all , 

we have exchange server 2013 with three CAS server and three mailbox Server . 

suddenly yesterday the mail flow was stopped to external and all mails stuck on the exchange queue . no changes happen to network and all port are open .

restart the mailbox server solve the issue .

but my concern is what could make the emails stop on the exchange queue ?

antivirus we have is McAfee and all are disabled . 



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